J Natl Cancer Inst. 1991 Jul 17;83(14):1036-7.

34、000人を対象としたコホート研究。「第７日アドベンチスト」というキリスト教団では、教えにより喫煙は禁じられている。入信時に禁煙した人と、過去に喫煙歴がない人を比較した。その結果、過去の喫煙者は白血病は２倍（1．01〜3.95, 95%信頼区間）、骨髄腫は3.01倍（1.13-8.05, 95%信頼区間）のリスク上昇があった。喫煙期間も相関がみられた。骨髄性白血病はもっともタバコとの関連が高く、2.24倍(0.91-5.53)であった。

Mills PK, Newell GR, Beeson WL, Fraser GE, Phillips RL.

Department of Preventive Medicine, School of Medicine, Loma Linda University, Calif.

The risks of leukemia and myeloma associated with cigarette smoking were evaluated in a cohort study of 34,000 Seventh-day Adventists. Although Seventh-day Adventists do not smoke by church proscription, many are adult converts who smoked cigarettes prior to their baptism into the church. In comparison with those who never smoked, ex-smokers experience a relative risk of 2.00 (95% confidence interval = 1.01-3.95) for leukemia and 3.01 (95% confidence interval = 1.13-8.05) for myeloma. Risks increased in a dose-response fashion with increasing numbers of cigarettes smoked daily for both leukemia (trend P = .009) and myeloma (trend P = .005). Also, the risks of both leukemia and myeloma increased with the total duration of cigarette smoking. The cigarette smoking-leukemia relationship was strongest for myeloid leukemia, for which ex-smokers experienced a relative risk of 2.24 (95% confidence interval = 0.91-5.53). These data lend support to the hypothesis that cigarette smoke may induce malignant degeneration in bone marrow and its products.

PMID: 2250299 [PubMed - indexed for MEDLINE]